Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R

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Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R.

Multiple myeloma (MM) is the most common cause of death from hematological malignancy worldwide, and recent studies have revealed that let-7b-5p can play an inhibitory role in tumorigenesis. However, the role of let-7b-5p in MM still remains unclear. The aim of this study was to elucidate the molecular mechanisms by which let-7b-5p acts as a tumor suppressor in MM. Here, quantitative real-time ...

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Objective: Endometriosis is a chronic disease that influences approximately 5-15% of women of reproductive age. Some studies have confirmed that numerous microRNAs (miRNAs) are unconventionally expressed in the ectopic endometrium. However, the accurate pathological mechanism of the effect of miRNAs on endometriosis is not completely clear. The aim of this study was to investigate the functiona...

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Let-7b Regulates Myoblast Proliferation by Inhibiting IGF2BP3 Expression in Dwarf and Normal Chicken

The sex-linked dwarf chicken is caused by the mutation of growth hormone receptor (GHR) gene and characterized by shorter shanks, lower body weight, smaller muscle fiber diameter and fewer muscle fiber number. However, the precise regulatory pathways that lead to the inhibition of skeletal muscle growth in dwarf chickens still remain unclear. Here we found a let-7b mediated pathway might play i...

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ژورنال

عنوان ژورنال: Acta Biochimica et Biophysica Sinica

سال: 2014

ISSN: 1745-7270,1672-9145

DOI: 10.1093/abbs/gmu089